Lipophilicity and Chromatographic Behaviour of Benzoic Acid Derivatives.

Docking of oxalyl aryl amino benzoic acid derivatives into PTP1B

Protein Tyrosine Phosphatases (PTPs) that function as negative regulators of the insulin signaling cascade have been identified as novel targets for the therapeutic enhancement of insulin action in insulin resistant disease states. Reducing Protein Tyrosine Phosphatase1B (PTP1B) abundance not only enhances insulin sensitivity and improves glucose metabolism but also protects against obesity ind...

Lipophilicity Studies on Thiosemicarbazide Derivatives.

The lipophilicity of two series of thiosemicarbazide derivatives was assessed by the RP-HPLC method with the RP-18 chromatographic column and the methanol-water mixture as the mobile phase. Distribution coefficients logPHPLC were compared to calculated values generated by commonly used AClogP software and quantum chemical calculations. The reliability of the predictions was evaluated using the ...

Chromatographic Retention Parameters as Molecular Descriptors for Lipophilicity in QSA(P)R Studies of Bile Acid

Acoustical Studies of Some Derivatives of 4-Amino Benzoic Acid in 1, 4-Dioxane and Dimethyl Formamide at 308.15 K

The ultrasonic velocity, density and viscosity of some Schiff bases of 4-amino benzoic acid  were measured in 1,4-dioxane and dimethylformamide at 308.15 K. Various acoustical properties such as isentropic compressibility (ks), Rao’s molar sound function (Rm), the Van der Waals constant (b), molar compressibility (W), inter molecular free len...

Synthesis and Structures of Three- and Hexa-armed Benzene Derivatives Featuring Lateral Benzoic Ester and Benzoic Acid Functions

The new 1,3,5-tri-substituted and hexa-substituted benzoic methyl esters 1, 3 and benzoic acids 2, 4 have been synthesized. Single-crystal structure determinations of 1 – 3 are reported, which show specific molecular conformations and packings in the crystal. In all structures, the conformation of the molecules deviates considerably from threefold and sixfold symmetry, respectively. Columnar pa...